![]() 0%) which are both statistically higher in the deceased cohort. The demographics of the two cohorts were similar except for older age (68 vs. Results: Of the 42 mechanically ventilated patients, majority (n=25, 60%) died. The two cohorts (alive and deceased) were compared using Chi-squared tests for categorical variables and 2-sample t-tests for continuous variables. Dead space was estimated using Penn State estimates, rearranged Weir, and alveolar ventilation equation as was validated by Beitler et al. Methods: This is a retrospective study in which 42 mechanically ventilated patients' dead space at day 0, day 1, and day 3 were calculated. In this study, we propose that the dead space fraction can predict mortality in patients with COVID- 19 respiratory failure requiring mechanical ventilation. In the wake of COVID-19, there has been postulation that the respiratory failure resulting from this disease might be different from ARDS. It has been shown in acute respiratory distress syndrome (ARDS) that dead space fraction predicts mortality. ![]() Usual reasons for mechanical ventilation are a combination of hypoxemia and ventilatory failure resulting in hypercapnia. ![]() COVID-19 in its severe state results in respiratory failure requiring mechanical ventilation. Rationale Coronavirus Disease 2019 (COVID-19) is a highly contagious respiratory illness resulting from infection by SARS-CoV2. ![]()
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